نوع المستند : بحوث علمية محکمة
المؤلفون
1
كلية التربية النوعية جامة المنوفية
2
كلية الاقتصاد المنزلي، جامعة المنوفية
المستخلص
This study was conducted to evaluate the chemical composition of watermelon (Citrullus lanatus) pulp and rind powders, as well as to investigate their potential therapeutic effects on gentamicin-induced nephrotoxicityin rats. Forty adult female albino rats (Sprague-Dawley strain) were divided into eight groups. The first group was normal rats as a negative control group, while the other seven groups were fed a basal diet and injected with gentamicin to induce nephrotoxicity. One of them was the positive group, while the remaining six groups were fed a basal diet supplemented with 2.5%, 5%, and 7.5% of either watermelon pulp or rind powder, respectively, for 28 days. The results revealed that the content of moisture, dietary fiber, carbohydrates, total calories, total phenols, total flavonoids, and 2,2-diphenyl-1-picrylhydrazyl (DPPH%) of watermelon pulp powder was significantly higher than its content in the rind powder. In contrast, the rind powder contained considerably higher concentrations of tested minerals, except for iron and potassium, which were more abundant in the pulp. In addition, levels of AST, ALT, ALP, GGT, urea, uric acid, creatinine, MDA, and blood glucose were dramatically decreased in the nephritic watermelon pulp-treated groups. In contrast, levels of TP, Alb, GPX, SOD, CAT, GSTs, and TAC were greatly increased. Regarding levels of K and P, they decreased while levels of Na and Ca increased in nephritic-treated groups with pulp and rind powder, especially at 7.5%. So, this study proved that pulp and rind powder are effective in treating kidney diseases and protecting against associated complications. It also contains many vital compounds that play an important and effective role in metabolic processes and performance during the life cycle.
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