Ameliorative Effects of Pomegranate Molasses and Fig on Carbon Tetrachloride Hepatotoxicity in Rats

نوع المستند : بحوث علمية محکمة

المؤلفون

1 زميل تخصص التغذية وعلوم الأطعمة،مستشفى جامعة حلوان.

2 قسم الصناعات الغذائية – كلية الزراعة – جامعة القاهرة –الجيزة

3 زميل تعليمي تخصص تغذية وعلوم الأطعمة، مستشفى الجلاء التعليمي.

المستخلص

The possible preventive effects of pomegranate and fig against hepatocellular toxicity induced by carbon tetrachloride CCl4 in male rats were studied. The pomegranate molasses and fig indicated the existence of flavonoid and phenolic components in their entirety. Each of the eight groups of rats contained six rats; group )1( served as the negative control, or normal group, and the rats in the other groups received subcutaneous injections of carbon tetrachloride (CCl4) twice weekly for six weeks to induce hepatocellular toxicity. Group (2) was left as a positive control, while the rest groups were administered with (2.5%, 5% and 10%) pomegranate molasses or dried fig , for 6 weeks, respectively. Blood samples were collected at the conclusion of the experiment for biochemical examination. The results showed that, in comparison to the normal control group, the rats with hepatocellular toxicity had significantly higher serum levels of AST, ALT, total protein, creatinine, and blood urea nitrogen. The administration of (2.5%, 5% and 10%) pomegranate and dried fig preserved liver caused a significant reduction in serum levels of AST, ALT, total protein, creatinine and blood urea nitrogen while an increase in hemoglobin and RBC was greater in pomegranate especially (10%) group. This study concluded that pomegranate and dried fig could be implemented in the protective effect of hepatotoxicity in rats and resume the anemic effect caused by CCl4. Therefore this study recommends Increased dietary intake of pomegranate and dried fig may be beneficial for patients with liver and kidney diseases as a preventative measure

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