Effect of Beta vulgaris L. roots and dietary L-glutamine on healing of peptic ulcer in experimental rats

نوع المستند : بحوث علمية محکمة

المؤلفون

1 كلية التربية النوعية جامعة المنوفية

2 كلية الاقتصاد المنزلى جامعة المنوفية

3 کلية التربية النوعية جامعة المنوفية

المستخلص

Abstract:
The effect of ethanolic extract of Beta vulgaris L. roots and dietary L-glutamine on healing of peptic ulcer in experimental rats has been investigated. Forty-two adult male albino rats, weighting (170:180g) of the Sprague Dawley Strain were employed and divided into 7 groups. Each group consisted of 6 rats, one was used as a negative control, and the others were administered aspirin orally (200 mg/kg B.Wt.). One of these groups was used as a positive control. In contrast, group (3,4) received dietary L-glutamine, group (5,6) received Beta vulgaris L. roots extract, and the last group was treated with omeprazole as a standard drug for 7 days. The length of the gastric ulcer, the volume of gastric juice, the pH value, the total acidity, and the histopathological changes of the stomach were investigated. Results confirmed that oral administration with both tested extracts reduced the length of gastric ulcer, the total acidity, the volume of gastric juice, and the histopathological changes. The highest curative ratio for gastric ulcer was obtained by a dose of 600mg/kg of Beta vulgaris L. roots extract compared with the omeprazole group. Our findings concluded that Beta vulgaris L. roots and dietary L-glutamine could be used for healing peptic ulcer.

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