BIOLOGICAL AND BIOCHEMICAL STUDY OF THE EFFECT OF CANAGLIFLOZIN AND SOME HERBAL COMBINATIONS ON MALE RATS WITH TYPE II DIABETES AND GOUT

نوع المستند : بحوث علمية محکمة

المؤلفون

1 كلية التربية النوعية جامعة المنوفية

2 كلية الاقتصاد المنزلي- جامعة المنوفية

3 كلية التربية النوعية- جامعة المنوفية

المستخلص

The main target of this study was to reduce the cost of treatment of diabetic and gout patients due to high drug prices. It was suggested to use herbal combinations (Ginger, Urtica Dioica (Nettle) Turmeric (Curcuma), Coffee (CoFFea), or DiLL (Anethum Graveolens), Melissa (Lemon Balm), Lemongrass (Cymbopogon Ciratus), Marjoram (Origanum Majorana)) with lowering the level of drug intake. Treatment cost calculated, and showed that drug decrease with giving herbs collection, especially the "B" collection reduced the cost of treatment. This was carried out on diabetic rats. Control "A" group (diabetic rats received plane diet without herbs or drug) showed higher, serum glucose, (VLDL), HDL, total protein, albumin, and SOD, and lower levels of triglycerides, cholesterol, LDL, ALT, AST, ALP, urea, uric acid, and creatinine. Nevertheless, feeding on the basal diet with drug 100 & 30, with combined herbs 100 or 300 mg reversed such changes. This was confirmed by the fewer histopathological changes. This indicated that suggested herbs especially the combined herb "A", may be used to lower the treatment cost of diabetics as calculation result revealed.

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